Synovial macrophages.
نویسندگان
چکیده
منابع مشابه
Macrophages in Synovial Inflammation
Synovial macrophages are one of the resident cell types in synovial tissue and while they remain relatively quiescent in the healthy joint, they become activated in the inflamed joint and, along with infiltrating monocytes/macrophages, regulate secretion of pro-inflammatory cytokines and enzymes involved in driving the inflammatory response and joint destruction. Synovial macrophages are positi...
متن کاملSynovial tissue macrophages: friend or foe?
Healthy synovial tissue includes a lining layer of synovial fibroblasts and macrophages. The influx of leucocytes during active rheumatoid arthritis (RA) includes monocytes that differentiate locally into proinflammatory macrophages, and these produce pathogenic tumour necrosis factor. During sustained remission, the synovial tissue macrophage numbers recede to normal. The constitutive presence...
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Peripheral blood monocytes and synovial macrophages obtained from 21 patients with rheumatoid arthritis and from 13 controls were cultured with autologous peripheral blood lymphocytes and stimulation measured by thymidine uptake. Rheumatoid macrophages and monocytes induced a small but significant degree of lymphocyte transformation, and those from the controls did not. The degree of stimulatio...
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Background. Beta-2-microglobulin (b2M) amyloidosis is a destructive articular disease affecting dialysis patients. The amyloid deposits contain both b2M and b2M altered with advanced glycation end products (AGE-b2M). We have shown that b2M increases the expression of matrix metalloproteinase-1, vascular cell adhesion molecule-1 and cyclooxygenase-2 in human synovial fibroblasts, while the effec...
متن کاملDecrease of CD68 Synovial Macrophages in Celastrol Treated Arthritic Rats
BACKGROUND Rheumatoid arthritis (RA) is a chronic immune-mediated inflammatory disease characterized by cellular infiltration into the joints, hyperproliferation of synovial cells and bone damage. Available treatments for RA only induce remission in around 30% of the patients, have important adverse effects and its use is limited by their high cost. Therefore, compounds that can control arthrit...
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ژورنال
عنوان ژورنال: Annals of the Rheumatic Diseases
سال: 1995
ISSN: 0003-4967
DOI: 10.1136/ard.54.5.392